A facile and high efficient synthesis of nitriles from aldoximes and primary amides with a mixture of triphenylphosphine/2, 3-dichloro-5, 6- dicyanobenzoquinone (PPh3/DDQ) under neutral conditions
نویسندگان
چکیده
Several methods have been reported for preparation of nitriles by dehydration of aldoximes using selenium dioxide-chloroform, diphosphorus tetraiodide, trifluoroacetic anhydride-pyridine, chlorosulphonyl isocyanate, 4,6-dipheny-2-methylthio-pyriliumtetrafluoro borate, copper (II) acetate-acetonitrile, trichloroacetyl chloride-triethylamine, triphenylphosphine/carbontetrachloride (PPh3/CCl4) in acetonitrile, montmorillonite KSF and Envirocat EPZG. Unfortunately, many of these reagents have limitations in forms of their economy and lack of availability, use of great excess of reagents, vigorous reaction conditions, longer reaction times and tedious work-up. Reagents such as triethylamine/sulfur dioxide and sulfuryl chloride fluoride allow the rapid and mild dehydration of aldehyde oximes but the preparation of the reagents is inconvenient (at 78C). Dehydration with zeolite (CsX) suffers from high temperatures (350°C) and reagents like phosgene, diphosgene and triphosgene are hazardous to use.
منابع مشابه
Ultrasound Promoted Efficient Synthesis of some Amides from Nitriles in Ambient Condition
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Maryam Sadat Ghasemzadeh was born in Ghaen/ Southern Khorasan, Iran. She received her B.Sc. in Pure Chemistry from Imam Khomeini International University and M.Sc. in Organic Chemistry from Birjand University under the supervision of Professor Sara Sobhani. She is currently studying her Ph.D. in Ferdowsi University of Mashhad under the supervision of Professor Batool Akhlaghinia. Her current re...
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